FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF PECTIN IN COMBINATION WITH OTHER HYDROPHILIC POLYMER
Author Name: *Chandra Kumar Chanchal, **Dr. Ishab Kumar
Volume: 01 & Issue:
Country: INDIA
DOI NO.: 08.2020-69739919, DOI Link: http://doi-ds.org/doilink/08.2020-69739919/
Affiliation:
- SBS Polytechnic and Pharmacy College, Patti, Punjab, India
- SBS Polytechnic and Pharmacy College, Patti, Punjab, India E-Mail: chandrapx123@gmail.com
ABSTRACT
Physico-chemical characteristics of pectin and guar gum were found to be within the specified limits. The guar gum showed passable compressibility index, high % of swelling and passable angle of repose as compared to pectin. Swelling and erosion experiment were carried out with tablets containing different ratios of guar to pectin using USP 24 Type II apparatus. From the result it was observed that guar gum has greater swelling capacity and pectin has high erosion rate. In-vitro drug release from the formulation batch F3 and F4s was found to be most promising and show optimum release in a controlled manner for 10 h. The formulation batch F4 shows the zero-order release. At the same polymer level (pectin and guar gum). The effect of different filler excipients were studied (batch F3). It was observed that tablets prepared with lactose shows faster release and recompress decrease the drug release from diltiazemHCl matrix tablets. All the formulation batches tested for physical parameters like weight variation, hardness, friability and drug content, all were found to be within the I. P. limits. The in-vitro drug release data showed that the optimized formulation batch F3 follows the Korsmeyer-peppas model, indicating that the possible mechanism of drug release was by non-Fickian diffusion. The optimized formulation batch F4 follows the zero order release. The drug-excipient interaction studies were carried out by FTIR and DSC. No significant interaction of drug with polymer was observed. During stability studies, no significant variation (1 to 3%) in drug release was observed, indicating that formulation batch F3 and F4 were stable over the chosen condition for 2 months. The optimized formulation batch F3 and F4 showed better drug release profile with Dilzem SR ( diltiazem HCL , Torrent) and Voveran SR ( diclofenac sodium ,Novartis) respectively. This was concluded from the similarity factor (f2), which was found to be 53.53 and 52.40 respectively.
Key words: Pectin , sustained release, Polymer, Formulation
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