ROLE OF TRANSITION METAL COMPLEXEX IN CHEMOTHERAPY AND IMMUNOTHERAPY

Author Name: 1Dr Mamta Rani Kaushik ,2Vimlesh Sharma

Volume: 01 &  Issue:

Country: India

DOI NO.: 08.2020-25662434 DOI Link: http://www.doi-ds.org/doilink/11.2020-94431798/

Affiliation:

1. Assistant Professor, Department of Chemistry, K.R.P.G.College,Mathura, India
2. Assistant Professor, Department of Chemistry, PatelShriTeekaram Degree College,Hardoi , India

ABSTRACT

For decades, transition coordination compounds have gained more and more attentions in the design of new metal Compound including innate immunity. By suppressing tumors and activating immune system homeostatic mechanisms. Chemotherapy may help overcome this tumor- induced immune tolerance. As such, chemotherapy may therefore support improved results from novel immune –modulating therapies. Immunotherapies, and in combining them with chemotherapy to achieve additive or synergistic clinical activity. Two major ways that chemotherapy promotes tumor immunity are by inducing immunogenic cell death as part of its intended therapeutic effect ,and by disrupting strategies that tumors use to evade immune recognition. This second strategy in particular is dependent on the Drug, its dose, and the schedule of chemotherapy administration in relation to antigen exposure or releastalse. In this cancer immunology at the crossroads article we focus on cancer vaccines and immune checkpoint blockade as a forum for reviewing preclinical and clinical data demonstrating the interplay between immunotherapy and chemotherapy. In the past, metal-based compounds were widely used In the treatment of disease conditions, but the lack of clear distinction between the therapeutic and toxic doses was a major challenge.

Key words: Chemothereapy,Immunotherapy,Metal Macrocyclic Complexes.