ASSOCIATION OF VARIABLES (DEMOGRAPHIC AND CLINICAL) WITH PLATINUM BASED CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY AMONG CANCER PATIENTS

Author Name: Ms. Rupinder Kaur

Volume/Issue: 03/05

Country: India

DOI NO.: 08.2020-25662434 DOI Link: https://www.doi-ds.org/doilink/11.2022-52373791/UIJIR

Affiliation:

Ph.D Scholar, FIPC, Associate Professor, Sri Guru Ram Das College of Nursing Sri Guru Ram Das University of Health Sciences, Mehta Road Vallah, Sri Amritsar, India

ABSTRACT

Chemotherapy-induced peripheral neuropathy (CIPN) is customarily observed, dose-related, nerve damaging side effect of chemotherapy that affects quality of life among cancer patients. There is 60–70% incidence rate of CIPN with platinum-based drugs; because these agents frequently used as first and second-line treatment for several common malignancies in cancer. Sixty (60) % of patient’s reports 2nd degree peripheral nerve damage whose had received total cumulative platinum-based drug dose ranges from 225–500mg. However, 30-40% of them experience treatment-emergent grade 3–4 neurotoxicity. Incidence rate of neurosensory symptoms related to oxaliplatin-induced neurotoxicity (OXAIPN) was 60%–75% among patients treated with platinum-based regimens. With the use of platinum-based chemotherapy sensation may continue to deteriorate even after end of treatment. Recent research data enumerated predisposing factors such as low pre-treatment hemoglobin and higher BMI, that leads to development of chemotherapy induced peripheral neuropathy very speedy irrespective of chemotherapeutic agent. So, based on this recent data, researcher has interest to compile a study based on association of variables with platinum-based chemotherapy induced peripheral neuropathy among cancer patients. The present study was carried out to fulfill the following objectives1To find out the association of demographic variables with platinum based CIPN among cancer patients. 2. To find out the association of clinical profile variables with platinum based CIPN among cancer patients.

Key words: Variables, Platinum, Chemotherapy Induced Peripheral Neuropathy, Cancer, Patients.