LASSA OR EBOLA: THE THREAT OF THE NEXT HUMAN PANDEMIC

Author Name: Sajad Khan1*, Rabia Hayat1**, Shahnaz Salamat1***, Yujun Liang1****

Volume/Issue: 02/07

Country: China

DOI NO.: 08.2020-25662434 DOI Link: https://www.doi-ds.org/doilink/01.2022-15856864/UIJIR

Affiliation:

1* Masters Student, College of Marine Life Science, Ocean university of China, Qingdao, China

1** PhD Scholar, Institute of Evolution and Marine biodiversity, Ocean university of China, Qingdao , China

1*** PhD Scholar, College of Marine Life Sciences, Ocean university of China, Qingdao, China

1**** Associate Professor, Department of Marine Biology, College of Marine Life Sciences, Ocean university of China, Qingdao, China

Email: sajadkhnan34@yahoo.com ,  liangyujun@ouc.edu.cn ,hayatrabia@stu.ouc.edu.cn , shahnazsalamat704@yahoo.com

ABSTRACT

LASV and EBOV are the two emerging zoonotic pathogens that caused an infection that results in a severe hemorrhagic fever (HF) in the people of Africa. Both Viruses have been reported more than 40 years ago, i.e. 1969 and 1976. It has been estimated that LASV is continuously emerging with more than 5 million cases and 5,000 deaths every year, whereas, until today, EBOV is responsible for a total of eleven outbreaks with more than 30, 000 cases and 15,000 deaths. However, Both Viruses re-emerging with more severity, fatality, and asymptomatic condition than previous, which is creating a considerable situation in the current world’s battle of SARS-Cov-2 pandemic. Therefore, our current review article aims to hypothesize the upcoming global outbreak of LASV or EBOV based on their current Immune genesis, pathogenesis, and epidemiological understanding. However, our understanding of pandemic and disease spreading of both viruses are limited, particularly the environmental factors that contribute, and the cellular and viral dynamics during transmission from natural reservoirs to humans, and last, the virology in humans is quite complicated. Therefore, improvement in the scientific collaboration and research activities, funding for projects, and encouragement of health ministries and the research institutes are necessary for better understanding the viruses. In last, a data-sharing platform should introduce for all researchers having an opportunity to share and conceptualized all the necessary materials related to pathogens, such as epigenetics, host-factor, genomics, and proteomics, which will contribute as an advantageous step towards the battle against Lassa or Ebola viruses.

Key words: LASV, EBOV, Pandemic, Hemorrhagic, Fever, Covid-19