ANTIMICROBIAL ACTIVITY OF ANDROGRAPHIS PANICULATA LEAF EXTRACT

Author Name: 1Dr. Ndubilo, Paul Chukwuemeka

Volume: 01 &  Issue:

Country: Philippines

DOI NO.: 08.2020-25662434 DOI Link: http://www.doi-ds.org/doilink/10.2020-69186357/

Affiliation:

1. University of Northern Philippines College of Medicine, Tamag, Vigan City, Philippines

ABSTRACT

The increasing proliferation of diseases, with the associated drug resistance, has underscored the need for new drug development. Andrographis paniculata is one of the medicinal plants with rich active diterpenoids for the potential discovery of new drugs. It is commonly used for its anti-inflammatory, antineoplastic, antioxidant, antipyretic, anti-hypertensive, antidiabetic, and immune-boosting properties. However, virtually no research has been done to unravel the antimicrobial properties of the plant. Thus, this research was done to investigate the antimicrobial activity of Andrographis paniculata. This study made use of the experimental research design in actual laboratory setup. Disk diffusion method was used to screen the antimicrobial activity of andrographis paniculata leaf extract against Staphylococcus aureus and Escherichia coli, with amoxicillin as the control. Fresh leaves of Andrographis paniculata were shade-dried, powered, and extracted using ethyl alcohol. The results revealed remarkable growth inhibitions of Andrographis paniculata against Staphylococcus aureus and Escherichia coli. My study demonstrates that Andrographis paniculata has antimicrobial activity against the test microorganisms. Therefore, the leaf extract can be used as an antibacterial agent for the diseases caused by these pathogens.

Key words: Antimicrobial activity, Andrographis paniculata (Klorostrep), Leaf extract, Staphylococcos aureus, Escherichia coli